Estrone Description

Estrone, one of the above beastly estrogens, is an aromatized C18 steroid with a 3-hydroxyl accumulation and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in borderline tissues (especially adipose tissue) through about-face of adrostenedione. Estrone may be added metabolized to 16-alpha-hydroxyestrone, which may be bargain to estriol by estradiol dehydrogenase.

Estrone, a synthetically able or by itself occurring steroidal estrogen acquired from abundant equine urine, is the primary circulating estrogen afterwards menopause. Estrone is by itself acquired from the borderline about-face of androstenedione by an aromatase enzyme begin in adipose tissues and is adapted to estradiol in borderline tissues. The estrogenic authority of estrone is one third that of estradiol. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to amusement abnormalities accompanying to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar decline associated with menopause, and for the blockage of osteoporosis due to estrogen deficiency.