Trazodone mechanism of action

Trazodone acts as a bifold 5-HT agonist and 5-HT reuptake inhibitor. Both trazodone and its metabolite m-chlorophenylpiperazine act on signal-sending neurons and on receptors amid on the message-receiving neuron. The action of trazodone on the synapses of the message-sending neuron prevents neurotransmitter re-uptake, abnormally of serotonin. In this way, it facilitates the supply of the bulletin to the destination receptor. This partly explains why trazodone is able in the test of depression.

The action on receptors amid forth the accepting neuron is addition of the drug-induced effects, including ancillary effects. In fact, if trazodone binds to appropriate types of such receptors, this abettor prevents the neurotransmitter - serotonin - from carrying the bulletin to the accepting neuron. With trazodone, the consistent pharmacological action is mostly sedative, and this ancillary aftereffect can be a account for patients, abnormally if they aswell ache from sleeplessness.