Flibanserin Hepatotoxicity

In placebo controlled trials, alarmist analysis abnormalities were no added accepted with flibanserin than with placebo treatment, and what abnormalities occurred were balmy and bound spontaneously, usually after charge for dosage interruption. During these premarketing analytic trials and back its added boundless analytic availability, no instances of astute alarmist abrasion with jaundice accept been appear attributable to flibanserin.

However, the absolute analytic acquaintance with flibanserin use has been limited. Many added serotonergic agents, such as the SSRIs, accept been active in attenuate instances of clinically credible alarmist injury. The cessation to access is about 1 to 8 weeks and the arrangement of enzyme elevations varies, alignment from cholestatic to hepatocellular. Balmy signs and affection of hypersensitivity (rash, fever, eosinophilia) are common, but usually not prominent. Autoantibody accumulation is rare. The advance is about self-limited and mild-to-moderate in severity, but fatalities accept been appear with some SSRIs. However, flibanserin itself has not been active in agnate cases.