D-cycloserine
is an amino acid analog antibiotic. D-cycloserine acts as a aggressive
inhibitor of D-alanine, an capital amino acid during peptidoglycan synthesis.
D-cycloserine is acrid in aqueous solution.
D-Cycloserine
inhibits corpuscle bank biosynthesis (D-Ala peptide band formation). The
terminal two amino acid residues of the murein forerunner lipid II abide of
D-alanine, which is produced by the enzyme alanine racemase; the two residues
are abutting by D-alanine ligase. Both enzymes are competitively inhibited by
cycloserine.
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