Levetiracetam Clinical Information

Levetiracetam is accustomed for test of partial, myoclonic, and tonic-clonic seizures, and is used off-label for berserk states and cephalalgia prophylaxis. Levetiracetam has actual favorable pharmacokinetics with acceptable bioavailability and accelerated accomplishment of abiding state. Its hepatic metabolism is basal and nonoxidative, authoritative it safe for use with hepatic agitator inducers or inhibitors. The above metabolite is a carboxylic acid derivate, which is abeyant and accounts for almost one division of the administered dose. Levetiracetam is excreted renally, with a beggarly half-life of 7 hours in adults and hardly beneath than that in children. Renal dysfunction may accreditation ameliorative ecology and/or dosage adjustment.

Given the abridgement of biologic interactions and agreeably pharmacokinetics, the primary uses for ameliorative biologic ecology of levetiracetam are acquiescence affirmation and administration of physiological changes such as puberty, pregnancy, and aging. Toxicities associated with levetiracetam use cover decreased hematocrit and red claret corpuscle count, decreased neutrophil count, somnolence, asthenia, and dizziness. These toxicities may be associated with claret concentrations in the ameliorative range.