Amifostine
is a prodrug that is dephosphorylated by acrid phosphatase in tissues to a
pharmacologically alive chargeless thiol metabolite. This metabolite is
believed to be amenable for the abridgement of the accumulative renal toxicity
of cisplatin and for the abridgement of the baneful furnishings of radiation on
accustomed articulate tissues.
The
adeptness of Amifostine to differentially assure accustomed tissues is
attributed to the college capillary acrid phosphatase activity, college pH and
bigger vascularity of accustomed tissues about to bump tissue, which
after-effects in a added accelerated bearing of the alive thiol metabolite as
able-bodied as a college amount connected for uptake into cells. The college
absorption of the thiol metabolite in accustomed tissues is accessible to bind
to, and thereby detoxify, acknowledging metabolites of cisplatin. This thiol
metabolite can aswell cruise acknowledging oxygen breed generated by
acknowledgment to either cisplatin or radiation.
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