CAS:
198470-84-7
Molecular
Formula: C19H18N2O4S
Molecular
Weight: 370.43
Parecoxib
is an injectable, nonsteroidal, anti-inflammatory biologic and COX-2 inhibitor.
Parecoxib has been advised for its capability in managing astute affliction in
humans with cancer.Parecoxib is a water-soluble and injectable prodrug of
valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a
COX2 careful inhibitor in the aforementioned class as celecoxib (Celebrex) and
rofecoxib (Vioxx). As it is injectable, it can be used perioperatively if
patients are clumsy to yield articulate medications. It is accustomed through
abundant of Europe for abbreviate appellation perioperative affliction
ascendancy abundant in the aforementioned way ketorolac (Toradol) is used in
the United States.
However,
clashing ketorolac, parecoxib has no aftereffect on platelet action and
accordingly does not advance bleeding during or afterwards surgery. In
addition, ketorolac has a abundant college gastrointestinal toxicity contour
compared to a lot of added nonsteroidal antiinflammatory drugs (NSAIDs)
including ibuprofen and naprosyn. While banned in abounding European countries
due to apropos about surgical bleeding and abdomen ulcers afterwards surgery,
ketorolac is the alone injectable NSAID in the United States.
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