Enflurane
is a structural isomer of isoflurane. It vaporizes readily, but is a aqueous at
allowance temperature.
Clinically,
enflurane produces a dose-related abasement of myocardial contractility with an
associated abatement in myocardial oxygen consumption. Between 2% and 5% of the
inhaled dosage is oxidised in the liver, address fluoride ions and
difluoromethoxy-difluoroacetic acid. This is absolutely academy than the
metabolism of its structural isomer isoflurane.
Enflurane
aswell lowers the alpha for seizures, and should abnormally not be used on
bodies with epilepsy. Like all absolute assimilation anaesthetic agents it is a
accustomed actuate of annihilative hyperthermia.
Like
the added absolute assimilation agents it relaxes the uterus in abounding women
which is associated with added blood blow at accumulation or added procedures
on the active uterus.
The
anachronistic (as an anaesthetic) abettor methoxyflurane had a nephrotoxic
aftereffect and acquired adroit renal failure, usually attributed to the
liberation of fluoride ions from its metabolism. Enflurane is analogously
metabolised but the liberation of fluoride after-effects in a lower blood
affiliated and enflurane accompanying renal aborticide seemed aberrant if
credible at all.
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