What is Clevudine?

Clevudine is a constructed pyrimidine alternation with action adjoin hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for assimilation into viral DNA, thereby causing DNA alternation abortion and inhibiting the action of HBV DNA polymerase (reverse transcriptase). Clevudine has a connected half-life and shows cogent abridgement of covalently bankrupt annular DNA (cccDNA), accordingly the accommodating is beneath acceptable to accept a backsliding afterwards analysis is discontinued.

Clevudine is an antiviral biologic for the analysis of hepatitis B (HBV). It is already accustomed for HBV in South Korea and the Philippines. It is marketed by Bukwang Pharmaceuticals in South Korea beneath the tradenames Levovir and Revovir.

Under authorization from Bukwang, Pharmasset was developing the drug, but its appearance III analytic balloon (international, multicenter, randomized, double-blind, 96-week QUASH studies) was concluded due to some myopathy cases in patients. Its approval in South Korea was revoked afterward these findings.[citation needed] Researchers in South Korea are testing clevudine at lower doses in aggregate with adefovir for connected use.It is a nucleoside analog.