Floxuridine Description

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of corpuscle division. This selectively kills rapidly adding cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents accustomed pyrimidines from getting congenital into DNA during the S appearance of the corpuscle cycle. Flurouracil (the end-product of catabolism of floxuridine) blocks an agitator which converts cytosine nucleosides into the deoxy derivative. In addition, DNA amalgam is added inhibited because fluoruracil blocks the assimilation of the thymdine nucleotide into the DNA strand.

Floxuridine is rapidly catabolized to 5-fluorouracil, which is the alive anatomy of the drug. The primary aftereffect is arrest with DNA amalgam and to a bottom extent, inhibition of RNA accumulation through the drug's assimilation into RNA, appropriately arch to the assembly of counterfeit RNA. Fluorouracil aswell inhibits uracil riboside phophorylase, which prevents the appliance of preformed uracil in RNA synthesis. As well, the monophosphate of floxuridine, 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) inhibits the agitator thymidylate synthetase. This leads to the inhibition of methylation of deoxyuridylic acid to thymidylic acid, appropriately interfering with DNA synthesis.