Moxonidine is a careful agonist at the
imidazoline receptor subtype 1 (I1). This receptor subtype is begin in both the
rostral ventro-lateral pressor and ventromedial depressor areas of the medulla
oblongata. Moxonidine accordingly causes a abatement in affectionate afraid
arrangement action and, therefore, a abatement in claret pressure.
Compared to the earlier central-acting
antihypertensives, moxonidine binds with abundant greater affection to the
imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds
to both receptors with according affinity.
In addition, moxonidine may aswell advance
sodium excretion, advance insulin attrition and glucose altruism and assure
adjoin hypertensive ambition agency damage, such as branch ache and cardiac
hypertrophy.
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