As a class, cephalosporins accept action
adjoin Gram-positive and Gram-negative bacteria. The antithesis of action tips
adjoin Gram-positive bacilli for beforehand generations; after ancestors of
cephalosporins accept added Gram-negative coverage. Ceftazidime is one of the
few in this chic with action adjoin Pseudomonas. It is not alive adjoin
methicillin-resistant Staphylococcus aureus.
In accession to the syn-configuration of
the imino ancillary chain, compared to added third-generation cephalosporins,
the added circuitous atom (containing two methyl and a carboxylic acidgroup)
confers added adherence to β-lactamase enzymes produced by abounding
Gram-negative bacteria. The added adherence to β-lactamases increases the
action of ceftazidime adjoin contrarily aggressive Gram-negative bacilli
including Pseudomonas aeruginosa. The answerable pyridinium atom increases
water-solubility. Ceftazidime shares the aforementioned capricious R-group
ancillary alternation with aztreonam, a monobactam antibiotic; the two drugs
allotment a agnate spectrum of activity, including action adjoin Pseudomonas.
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