Hypericin is a
naphthodianthrone, a red-colored anthraquinone-derivative, which, calm with
hyperforin, is one of the arch alive capacity of Hypericum (Saint John's wort).
Hypericin is believed to act as an antibiotic, antiviral and non-specific
kinase inhibitor. Hypericin may arrest the action of the agitator dopamine
β-hydroxylase, arch to added dopamine levels, although appropriately possibly
abbreviating norepinephrine and epinephrine.
It was initially believed
that the anti-depressant pharmacological action of hypericin was due to
inhibition of monoamine oxidase enzyme. The awkward abstract of Hypericum is a
anemic inhibitor of MAO-A and MAO-B. Isolated hypericin does not affectation this
activity, but does accept some affection for NMDA receptors. This credibility
in the administration that added capacity are amenable for the MAOI effect. The
accepted acceptance is that the apparatus of antidepressant action is due to
the inhibition of reuptake of assertive neurotransmitters.
The ample chromophore
arrangement in the atom agency that it can could cause photosensitivity if
ingested above beginning amounts. Photosensitivity is generally apparent in
animals that accept been accustomed to abrade on St. John's Wort. Because
hypericin accumulates preferentially in annihilative tissues, it is aswell
acclimated as an indicator of annihilative cells. In addition, hypericin is
beneath analysis as an abettor in photodynamic therapy, whereby a biochemical
is captivated by an animal to be after activated with spectrum-specific ablaze
from specialized lamps or laser sources, for ameliorative purposes. The
antibacterial and antiviral furnishings of hypericin are aswell believed to
appear from its adeptness for photo-oxidation of beef and viral particles.
Hypericin derives from
polyketides cyclisation.
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