Azacitidine Toxicity

Azacitidine causes anemia, neutropenia, and thrombocytopenia (low platelet counts), and patients should accept common ecology of their complete claret counts, at atomic above-mentioned to anniversary dosing cycle. The dosage may accept to be adapted based on base counts and hematologic response.

It can aswell be hepatotoxic in patients with astringent alarmist impairment, and patients with all-encompassing alarmist tumors due to metastatic ache accept developed accelerating hepatic blackout and afterlife during azacitidine treatment, abnormally if their albumin levels are beneath than 30 g/L. It is contraindicated in patients with avant-garde cancerous hepatic tumors.

Renal toxicity, alignment from animated serum creatinine to branch abortion and death, accept been appear in patients advised with intravenous azacitidine in aggregate with added chemotherapeutic agents for altitude added than myelodysplastic syndrome. Renal tubular acidosis developed in 5 patients with abiding myelogenous leukemia (an crooked use) advised with azacitidine and etoposide, and patients with renal crime may be at added accident for renal toxicity. Azacitidine and its metabolites are primarily excreted by the kidneys, so patients with renal dearth should be carefully monitored for added ancillary effects, back their levels of azacitidine may progressively increase.

Based on beastly studies and its apparatus of action, azacitidine can could could cause astringent fetal damage. Sexually alive women of changeable abeyant should use contraception during while accepting azacitidine and for one anniversary afterwards the endure dose, and sexually alive men with changeable ally of changeable abeyant should use contraception during analysis and for three months afterward the endure dose.

Azacitidine can aswell could could cause nausea, vomiting, fevers, diarrhea, bloom at its bang sites, constipation, bruising, petechiae, rigors, weakness, abnormally low potassium levels in the bloodstream, and abounding added ancillary effects, some of which can be astringent or even fatal.