Properties
of hyaluronic acid were aboriginal bent in the 1930s in the class of Karl
Meyer. Hyaluronic acid is a polymer of disaccharides, themselves composed of
D-glucuronic acid and N-acetyl-D-glucosamine, affiliated via alternating β-(1→4)
and β-(1→3)
glycosidic bonds. Hyaluronic acid can be 25,000 disaccharide repeats in length.
Polymers of hyaluronic acid can ambit in admeasurement from 5,000 to 20,000,000
Da in vivo. The boilerplate atomic weight in animal synovial aqueous is 3–4 actor Da, and hyaluronic acid
antiseptic from animal umbilical bond is 3,140,000 Da. Hyaluronic acid aswell
contains Silicon, alignment amid 350μg/g to 1900μg/g depending on area in the
organism.
Hyaluronic
acid is agilely stable, in allotment because of the stereochemistry of its
basic disaccharides. Bulky groups on anniversary amoroso atom are in sterically
advantaged positions, admitting the abate hydrogens accept the less-favorable
axial positions.
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