Nateglinide mechanism of action

Nateglinide increases insulin absolution by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner.

Nateglinide action is abased on the attendance activity β beef and glucose. In adverse to sulfonylurea insulin secretatogogues, nateglinide has no aftereffect on insulin absolution in the absence of glucose. Rather, it potentiates the aftereffect of extracellular glucose on ATP-sensitive potassium approach and has little aftereffect on insulin levels amid commons and overnight. As such, nateglinide is added able at abbreviation postprandial claret glucose levels than abnegation claret glucose levels and requires a best continuance of analysis (approximately one month) afore decreases in abnegation claret glucose are observed. The insulinotropic furnishings of nateglinide are accomplished at average glucose levels (3 to 10 mmol/L) and it does not access insulin absolution already angry by top glucose concentrations (greater than 15 mmol/L). Nateglinide appears to be careful for pancreatic β beef and does not arise to affect ashen or cardiac beef or thyroid tissue.