Neomycin sulfate (CAS 1405-10-3) Description

Synonym:   Neomycin B sulfate

CAS Number:      1405-10-3

Purity:    ≥85% Neomycin B, remainder Neomycin C

Molecular Weight:     908.88

Molecular Formula:    C23H46N6O13·3H2SO4

Solubility:      Soluble in water (50 mg/ml), ethanol (0.10 mg/ml), methanol (0.23 mg/ml), isopropanol (0.08 mg/ml), isoamyl alcohol (0.25 mg/ml), and benzene (0.05 mg/ml). Insoluble in acetone, chloroform, and ether.

Storage:   Store at 4° C

Melting Point:   Heat labile

Application:     A highly active antibiotic against gram-negative bacteria often used in cell culture

Description:

Neomycin sulfate is an aminoglycoside antibacterial and calcium approach protein inhibitor. Neomycin sulfate aswell binds to prokaryotic ribosomes inhibiting adaptation and is able adjoin gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via bounden to inositol phospholipids. It aswell inhibits phosphatidylcholine-PLD action and induces Ca2+ mobilization and PLA2 activation in animal platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.