Honokiol Description

Honokiol is the alive assumption of magnolia abstract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation.

Honokiol shows pro-apoptotic furnishings in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, articulate squamous corpuscle blight and colon blight corpuscle lines. Honokiol is able on inducing apoptosis in SVR angiosarcoma cells. Analysis of SVR beef with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by acrid antibodies to TRAIL. Honokiol aswell has absolute antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. Honokiol causes apoptosis in CLL beef through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated adaptation of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. Honokiol kills myeloma beef from relapsed patients at doses that does not annihilate PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as able-bodied as PARP cleavage. Honokiol is begin to abet apoptosis in the colon blight corpuscle curve RKO. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits aggression through accentuation of nuclear factor-kappaB activation pathway. Honokiol may act as a almighty anti-inflammatory abettor with multipotential activities due to an inhibitory aftereffect on the PI3K/Akt pathway.