Vitronectin is a ample
glycoprotein begin in claret and the extracellular cast (ECM). The gene for
vitronectin encodes a 19 amino acerbic (aa) arresting peptide and a 459 aa
protein. The amino terminal 130 aa of Vitronectin contains assorted bounden
sites for a array of structures. The credible atomic weight of animal
vitronectin is 75 kDa, with ~30% of its atomic accumulation getting attributed
to glycosylation at 3 altered sites. In claret and plasma, Vitronectin is begin
predominantly as a individual alternation monomer.
Vitronectin, aswell alleged
serum overextension agency or accompaniment S-protein, is a 75-kD glycoprotein
in claret and tissue. It is a multifunctional protein that mediates
cell-to-substrate adhesion, inhibits the cytolytic activity of the terminal
accompaniment avalanche in vitro, and binds to several serine protease
inhibitors of the serpin family, e.g., antithrombin III (AT3; 107300),
plasminogen activator inhibitors I and II , heparin cofactor II (HCF2; 142360),
and protease nexin.
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